CNS Regeneration

Core Competencies

- Test and model systems for cerebrovascular diseases

- Test and model systems for degeneration and regeneration of nerve pathways

Brief Desription

The CNS Regeneration working group has set itself the goal of developing new therapeutic options to treat stroke, to combat brain haemorrhages, vascular dementia and other neurological diseases. These are a global burden for patients, their families and society as a whole. Innovative research approaches and methods will contribute to a better understanding of the nervous system in order to develop innovative therapies that contribute to neuroprotection, regeneration and restoration of motor and cognitive performance in these devastating neurological diseases.

In the field of test and model systems for cerebrovascular diseases, the group works on improving existing models and supplementing them with newly developed models. This should increase the predictive power of preclinical experiments with regard to the clinical situation. For example, research is being carried out into how intracranial pressure can be reliably measured in animal models and how its increase can be modelled in a cell culture system, as this is an important phenomenon in brain hemorrhages.

Another field of work of the CNS Regeneration group is the development of test and model systems for the degeneration and regeneration of nerve pathways. An increasing number of studies have shown that many neurological diseases not only lead to the loss of nerve cells, but also to damage of nerve pathways.

These sometimes take place far away from the actual damage and can lead to impairment of the patient's motor and cognitive performance.

Up to now, it has not been possible to systematically investigate these damage to nerve pathways and their regeneration with a high data density and relatively high throughput. The research group is therefore developing a suitable high-content screening method in order to test substances that prevent damage and contribute to the regeneration of damaged nerve pathways.

 

 

Forschungsprojekte

Investigation of damage and regeneration of nerve pathways

Many neurological diseases result in damage to nerve conduction pathways, which restrict the restoration of the patient's motor and cognitive performance. The EMB is developing test systems to systematically investigate the damage and regeneration of nerve pathways with a high data density and relatively high throughput.

Model systems for cerebral hemorrhage

Brain hemorrhages are strokes caused by bleeding in brain tissue. They account for only about 15% of all strokes, but have the highest mortality rate (about 40% within a month). Despite growing knowledge of the underlying mechanisms, the transfer to suitable therapies has so far been very limited. The EMB is working on the development of high-precision and predictive model systems to investigate new diagnostic and therapeutic methods.