The cell differentiation working group was able to open up a new cell source for regenerative medicine with human stem cells from sweat glands. The particular advantage of sweat gland derived stem cells lies in their easy accessibility and ethical harmlessness. Animal experiments have already shown a positive effect on wound healing.
In particular, the regeneration of blood vessels (revascularisation) could be accelerated by stem cell treatment in animal experiments. Studies have shown that the effect of stem cells is largely due to soluble (paracrine) factors, which are released by the stem cells in the wound environment.
In addition, coculture studies have shown that stem cells have a positive influence on the regeneration of peripheral nerves. The stem cells thus strengthen the natural wound healing process many times over. In the future, stem cells from sweat glands will be made available for clinical applications.
Another branch of research of the cell differentiation working group is the development of new in vitro test systems. Due to the EU-wide ban on animal testing for applications in the cosmetics industry and the strong demand for aluminium-free deodorants, the need for new in vitro skin test systems has risen sharply in recent years.
Due to the long-standing and worldwide unique expertise in the field of stem cell isolation from glands and the production of organoids, cell technology know-how is available which can be used for the development of new test systems.