Establishment and Optimization of Organotypic Test and Model Systems

In the future, the need for alternative methods to animal experiments will increase sharply. Organotypic test systems are an attractive alternative to existing animal models and can help meet this increasing demand. The working group established manufacturing and culture conditions for organoids and organotypic tissue sections from various tissues and allows the detection of functional tissue parameters (e.g., electrophysiology).

- Design and development of cell-based and organotypic test and model systems for research and clinical use

- Non-invasive characterization of electrophysiologically active cells and tissues using microelectrode arrays and patch clamp

- Molecular biological examination methods (array-based analysis, immunohistochemistry, qPCR)

- Drug development (pharma, cosmetics)

- Safety assessment of substances (pharmaceuticals, cosmetics, chemicals)

See also:

Working Group "Cell Differentiation"